CYSTIC FIBROSIS - A DISORDER OF MEMBRANE TRANSPORT
A great variety of proteins have roles in moving molecules and ions across cell membranes. Passive transport proteins permit certain substances to diffuse down concentration gradients by moving through the protein's interior. Active transport proteins use ATP energy to pump substances across the membrane against their concentration gradients. To investigate the importance of transport proteins, we will consider the effects of cystic fibrosis, a genetic disorder in which there is a defect in a transport protein..
Activity
Part 1.
In this part of the activity you will visit the Cystic Fibrosis Foundation’s web site to learn about the causes and symptoms of cystic fibrosis.
Use your browser to go to http://www.cff.org/home/
Use the information provided in the “About cystic fibrosis” section to answer the following questions:
1. What are the signs and symptoms of cystic fibrosis?
Very salty tasty skin. Wheezing and shortness of breath.
2. How common is this disorder?
The disorder is not that common. Only 30,000 people in america and 70,000 world wide.
3. How is cystic fibrosis diagnosed?
By a fat protein that is no good. It causes thick mucus in your lungs and digestive system.
4. How is cystic fibrosis inherited? Does everyone who has a mutant gene for the protein have cystic fibrosis?
Its a fallen protein gene. Yes everyone who has a the protein has cf
Part 2.
In this part of the activity you will read an article to learn more about cystic fibrosis.
Use your browser to go to:
Use the information in this article to answer the following questions:
1. Explain the normal function of the protein that is defective in cystic fibrosis.
poorly permeable to chloride ions
2. What happens to this protein in CF patients and what are the consequences for the health of these individuals?
The channel is blocked
Part 3.
In this part of the activity you will read about how cystic fibrosis is treated.
Use your browser to go to:
Use the information in the different sections of the article to answer the following questions:
1. Explain at least 3 treatments for the symptoms of cystic fibrosis.
You get breathless, wheezing, and repeated lung infections.
2. Discuss at least 3 ways for parents to help their children who have cystic fibrosis.
Join a club that has meetings that help explain their problems, have them eat extra salt in hot weather, and don't smoke.
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